Tidbits Grand Forks - February 5, 2015

Page 8

NIACIN (continued): • Goldberger went one step further to prove pellagra was not contagious. He collected 16 volunteers, including his wife and himself, who did everything to contract pellagra through injections and secretions and bodily contact with sufferers. No one got the disease.

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• Goldberger spent the rest of his life in the laboratory trying to discover what factor meat, milk, and egg yolks had in common. By 1926, Goldberger established that a small amount of brewer's yeast prevented pellagra, yet he never knew why.

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• It was Conrad Elvehjem who discovered that pellagra is caused by a lack of the B vitamin niacin. He presented his findings in 1937, eight years after Joseph Goldberger's death.

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• Goldberger is remembered as the "unsung hero of American clinical epidemiology." Although he was nominated five times for the Nobel Prize, his discovery proved socially and politically unacceptable, and he made little progress in gaining support for the treating of pellagra during his lifetime. © 2015 King Features Synd., All rights reserved.

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• Pellagra is still found today, especially in third world countries that depend primarily upon corn for their sustenance. Refugees and prisoners receiving inadequate food commonly suffer from it. Alcoholism and drug addiction can also cause pellagra, as can intestinal disorders. Untreated, the disease can kill within four or five years.

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• Besides meat and eggs, niacin is found in avocados, dates, tomatoes, leafy vegetables, broccoli, sweet potatoes, asparagus, nuts, whole grains, and legumes.

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• Between 1906 and 1940 more than 3 million Americans were affected by pellagra with more than 100,000 deaths, yet the epidemic resolved itself after authorities decided to add niacin to bread in 1938.

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