MIND&BODY
FOOD
Got a bike? Like to dance? Join the celebration » PAGE 3
Reviews of the food trucks of Upper Haight » PAGE 8
SF Bike Party is On
IN THIS ISSUE
Off the Grid
News Briefs » PAGE 3 Journal Club » PAGE 5 Puzzles » PAGE 9
Synapse The UCSF Student Newspaper
Thursday, October 3, 2013
synapse.ucsf.edu
Volume 58, Number 4
NEWS
NEWS
NIH Official Warns of Challenging Times Ahead Chancellor Maps Out an Exciting Course for UCSF
By Alexandra Greer Science Editor
B
iomedical scientists face a multifaceted crisis of funding that threatens to slow the pace of discovery and discourage talented researchers from entering the biomedical workforce. Despite this bleak outlook, “We cannot let science get ahead of us,” said Dr. Sally Rockey, the Deputy Director for Extramural Research of the National Institutes for Health (NIH), during a seminar for UCSF researchers on September 24. During her presentation, which was part pep talk and part reality check, Rockey outlined both the mounting fiscal difficulties and attempted workarounds at the NIH in supporting biomedical research. Impact of sequestration
By Brian Shaw Staff Writer
C
30 percent. For 2012, after a significant slowdown in growth, current award estimates stand at around 18 percent of grant applications. “While the budget has gone up by some, our buying power has gone down, because of the cost of research,” said Rockey. In addition, large purchases for equipment or facilities expansions by laboratories
NEWS
OPINION
By Catherine Chiu Contributing Writer
T
he first time I walked into a patient room at Moffitt Hospital was during my first week as a medical student. For those of you who are not familiar with the Medical School curriculum, Foundations of Patient Care (FPC) is a two-year long course that teaches us the etiquette of being a doctor, in addition to how to think like a doctor. In FPC, the first patient interviews we conduct are in a small group of eight, in a small cramped hospital room at Moffitt or Long. We walk into the patient’s room in our white coats, and we hide in our pockets the fear of accidentally doing or saying something uncouth. I have met incredible and inspiring patients whose generosity to teach medical stu-
POWER OF MUSIC » PAGE 4
ROCKEY » PAGE 6
CHANCELLOR » PAGE 7
Photo by Cindy Chew/UCSF Dr. Sally Rockey, Deputy Director for Extramural Research at the National Institutes of Health, delivers a lecture, "NIH: Interesting Times, Challenging Times" at Genentech Hall on Sept 24.
Since last year, sequestration has resulted in the loss of 5 percent of NIH extramural funds, which has translated into a reduction in the number of awards made and also in the size of individual awards. These cuts (largely due to the sequester) come at a time when biomedical research is already reeling from a sharp drop in the success rates of grant awards. In the period 1998-2003, the NIH budget doubled and award rates stood at around
The Healing Power of Music
and institutions during those relative times of wealth have made it more difficult to adjust to a slowdown in new awards. “If we had only grown by 3 percent a year, we would still be near where we are today, and it would have been easier to adjust”, she said. “We prefer steady growth. Flat becomes problematic.” Despite these difficulties, the NIH remains
hancellor Desmond-Hellmann opened her fourth annual State of the University speech with what she called “some good news,” the launch of the Discovery Fellows Program, thanks to a significant donation from Sir Michael Moritz and his wife, Harriet Heyman. This program, funded by a gift of $60 million, will create the largest endowed program for PhD students in the history of the University of California system. It will ensure that UCSF can attract top PhD candidates and allow students the flexibility to work on more risky and innovative projects. UCSF Chancellor Susan Desmond-Hellmann delivered her fourth annual State of the University address on September 24. In a new format, she focused on headlines of the past year as a way to highlight individuals and initiatives at the university. In addition to the latest fund-raising success, Desmond-Hellmenn talked of the achievements of UCSF in the field of precision medicine. Most notably, the Chancel-
The Action Potential: The Ex Factor
aka “Why It’s OK You’re Still Sleeping with Your Ex” Editor's note: Using personal experiences as a guide, this column seeks to advise and entertain its readers on the ever-complicated topics of love and sex. The anonymity of "The Action Potential" provides our writers the freedom to recount completely and honestly even the most sordid tales. If you have any topics you would like to see covered, email synapse@ ucsf.edu. We'll find someone who's done the "dirty" work so you don't have to!
W
e’ve all sat in front of our T V or computer screen watching this show or that movie, completely enthralled by the unfolding drama of a relationship gone sour. Suddenly, some incident occurs — a night out at the same club; a run-in at a mutual friend’s party; assigned seats next to each other on the same plane — and the exes find
themselves talking and wind up waking up the next day sharing the same bed. If you are like me, this either made you fist-pump the air a few times in celebration or shake the screen in frustration at the idiocy of it all, while silently telling yourself that you would never fall into that trap. Nowadays, I would be a hypocrite to do the latter. I have become one of those characters I used to criticize. And despite the fact that I mentally berate myself time and again for falling into the trap of his embrace, I am unable (maybe unwilling is the better word) to stop, no matter how much it hurts each morning — after which he leaves me again. Which causes me to ask, “Why?” After discussing my slip-ups with friends, my question is no longer about my lack of willpower, but about why I was so critical of the practice of hooking up with an ex in the
first place. The most common response I receive is a shrug and the super-sympathetic statement, “It happens. Eat some chocolate.” Maybe I am just trying to justify my actions to assuage any lasting feelings of guilt, but I’d like to play devil’s advocate here, and say that, as long as neither of you are tied to someone new, hooking up with an ex is an acceptable source of pleasure and stress relief — if certain things are discussed beforehand. I truly believe communication is the problem and not the act itself. Due to the — ahem — extremely passionate and spontaneous nature of most hook-ups, the pre-coitus discussion is usually zero, or about everything but the one topic that really needs to be hashed out: the aftermath. I know that there is a reason we are not together, I know we are both lonely and horny
EX FACTOR » PAGE 6
2 | October 3, 2013 | synapse.ucsf.edu
EVENTS MISSION BAY EVENTS SPEED FRIENDING
Thursday, Oct. 3, 5:30-6:45 p.m., Housing Community Room, Mission Bay Would you like to meet new people at UCSF in a relaxed, casual environment? If your answer is yes, attend Speed Friending to meet international and domestic students and scholars in the UCSF community. Attendees will have the opportunity for quick chats with multiple people. Free appetizers and beverages will be provided with RSVP. speedfriendingucsf.eventbrite.com/.
OUTDOOR MOVIE AT MISSION BAY: MONSTERS UNIVERSITY
Thursday, Oct. 3, 6:30 p.m., Koret Quad, Mission Bay Enjoy a free screening of the delightful Pixar animated film Monsters University. This prequel is about how Mike (voiced by Billy Crystal) and Sulley (voiced by John Goodman) met and eventually became friends. Free hot dogs while supplies last (first come, first served) and snacks for sale.
SYNAPSE NEWSPAPER
Friday, Oct. 4, noon-1 p.m., Graduate Division Conference Room, third floor, Mission Bay Community Center Synapse is looking for Mission Bay and Parnassus writers, bloggers, photographers and designers. Come to the lunch meeting, share your story ideas and enjoy a free lunch. For details, email synapse@ucsf.edu.
MUSLIM FRIDAY PRAYER SERVICES
Friday, Oct. 4, 1-2 p.m., Helen Diller, 160, Mission Bay The Muslim Community at UCSF holds regular Friday prayer services (Jum’a) for the UCSF Muslim community every week. Join your fellow brothers and sisters for prayer, lunch and socializing. All are welcome.
MISSION BAY RIPS
Friday, Oct. 4, 3:30-5:30 p.m., Genentech Hall Auditorium, Mission Bay Research In Progress Seminar (RIPS) is a seminar series at which one student and one postdoc present their current research. Talks are 15 minutes in length and are preceded by a 20-minute social. Snacks and beverages are provided.
FOURTH ANNUAL LGBTQI MIXER
Friday, Oct. 4, 5:30-8 p.m., Rutter Center Gym, rooftop, Mission Bay Please join us for food, drinks, entertainment, raffle prizes and rock climbing. Sponsored by The LGBT Resource Center, Mission Bay Student Services, Student Health & Counseling, Gay Straight Dental Association and the LGBTQ Student Association.
MENTAL HEALTH AWARENESS WEEK
Monday, Oct. 7, 11:30 a.m.-1:30 p.m., Byers Hall, second-floor lobby, Mission Bay Enjoy some cookies, and learn more about mental health wellness and resources.
UNWIND: STRESS MANAGEMENT FOR WOMEN
Monday, Oct. 7, noon-1 p.m., Student Health and Counseling Services, Rutter Center, third floor, Mission Bay Take a breather! Student Health & Counseling offers this stress management workshop designed for women who are UCSF students. Learn helpful techniques to manage your stress from Felicia de la Garza Mercer, PhD.
This workshop will focus on Self-Talk and Rational Thinking. Free lunch for students who RSVP to felicia.mercer@ucsf.edu.
BAGEL TUESDAYS
Tuesday, Oct. 8, 8:30-10 a.m., Student Lounge, Genentech Hall, Mission Bay Come enjoy some free bagels, pastries and coffee. Learn about campus services and events and build a community at Mission Bay.
MISSION BAY FARMERS’ MARKET
Wednesday, Oct. 9, 10 a.m.-2 p.m., Gene Friend Way Plaza, Mission Bay Shop healthy, shop fresh, shop Californiagrown at the UCSF Farmers’ Market every Wednesday (rain or shine). Sponsor: Pacific Coast Farmers’ Market Association.
PARNASSUS EVENTS VENDOR SHOWCASE
Thursday, Oct. 3, 11 a.m.-2 p.m., Saunders Court, Parnassus Visit the Vendor Showcase and enjoy a scoop of Fenton’s Famous Ice Cream. Vendors will show off their best products, designed to make labs more productive. Giveaways include a mountain bike, Kindle, iPad and Safeway Gift Cards.
KOREAN AMERICAN CLUB RECRUITING
Friday, Oct. 4, 5:30-7:30 p.m., Faculty Alumni House, Parnassus The Korean American Health Professional Society will introduce the organization to interdisciplinary students. KAHPSA is recruiting more volunteers for the annual health fair and to share new ideas for its annual Korean Culture show, social event and Patbingsu night.
SONRISE CHRISTIAN FELLOWSHIP WELCOME NIGHT
Thursday, Oct. 3, 6-8:30 p.m., Health Science West, 303, Parnassus Enjoy delicious food catered by Limetree, while learning more about UCSF’s Sonrise Christian Fellowship, at its welcome event. Meet other UCSF students who are seeking to learn more about God and grow together as a community. This event is open to everyone. Email isaac@sfsonrise.org to join listserv.
NATIONAL DIVERSITY DAY
Friday, Oct. 4, 11:30 a.m.-1:30 p.m., Saunders’s Court, Parnassus Oct. 4 is National Diversity Day. Come spend it in Saunders Court with food, music and fun. Learn about the wonderful work our student RCOs are doing at UCSF and beyond. Special lunch deal from Carmelina’s.
PET THE PUP AT DOG DAY AFTERNOON
Friday, Oct. 4, noon-2 p.m., Millberry Union, 111W, Parnassus There will be a pup every Friday in October, so don’t miss out. Take time to de-stress with Judd, a Scottish terrier from Animal Assisted Therapy of SPCA. Enjoy some tea or hot chocolate, and leave your stress at the door. Sponsor: Student Life Services
MUSLIM FRIDAY PRAYER SERVICES
Friday, Oct. 4, 1:30-2 p.m., Medical Sciences, 180, Parnassus The Muslim Community at UCSF holds regular Friday prayer services (Jum’a) for the
UCSF Muslim community every week. Join your fellow brothers and sisters for prayer, lunch and socializing. All are welcome.
ASUC & GSA WELCOME PICNIC
Saturday, Oct. 5, noon-2 p.m., Saunders Court, Parnassus The Associated Students of UCSF (ASUC) and the Graduate Students’ Association (GSA) invite all new students to kick off the new school year with a welcome picnic. Come explore your new backyard, eat (free) delectable SF treats and meet new friends. Open to all first-year students.
MENTAL HEALTH AWARENESS WEEK
Monday, Oct. 7, 11:30 a.m.-1:30 p.m., Medical Science, Lobby, Parnassus Enjoy some cookies and learn more about mental health wellness and resources.
SNPHA SOCIAL
Monday, Oct. 7, 5-8 p.m., Medical Science, S-163, Parnassus The Student National Pharmaceutical Association will host a social for its members to get acquainted with the organization’s leaders and its upcoming events.
ASUC MEETING: DENTISTRY, MEDICINE & PHARMACY STUDENTS
Monday, Oct. 7, 5:30 p.m., Library, CL 221, Parnassus Meet your executive board members at the monthly ASUC meeting and become a part of the discussion on topics relating to student priorities. Visit the ASUC website for more details and to RSVP. asuc.ucsf.edu/.
GSA MEETING: GRADUATE, NURSING & PT STUDENTS
Tuesday, Oct. 8, 5:30 p.m., Library, 220, Parnassus Meet your executive board members at the monthly GSA meeting and become a part of the discussion on topics relating to student priorities. Visit the GSA website for more details and to RSVP: gsa.ucsf.edu.
CRACKING THE CODES: THE SYSTEM OF RACIAL INEQUITY
Tuesday, Oct. 8, 5:30-7:30 p.m., Cole Hall, Parnassus Dr. Shakti Butler, director of “The Way Home: Women Talk About Race in America,” will facilitate a deep dialogue and film screening of “Cracking the Codes: The System of Racial Inequity.” Sponsors: Multicultural Recourse Center and Program in Medical Education for the Urban Underserved. RSVP: http://bit. ly/15GFnbq
BAGEL WEDNESDAYS
Wednesday, Oct. 9, 9 a.m.-10:15 a.m., Health Sciences West Lobby, Parnassus Come enjoy some free bagels, pastries and coffee. Learn about campus services and events and build a community at Parnassus.
PARNASSUS FARMERS’ MARKET
Wednesday, Oct. 9, 10 a.m.-3 p.m., ACC, 400 Parnassus Ave. Shop the Farmers’ Markets on Wednesdays to pick up locally grown produce and more. Sponsor: Pacific Coast Farmers’ Market Association.
FLAVORFUL FALL NUTRITION SERIES: SPORTS NUTRITION
Wednesday, Oct. 9, noon-1 p.m., Nursing, 527, Parnassus Student Health and Counseling offers this one-time workshop. Take the first steps toward achieving a healthy weight, presented by Student Health’s Dietitian. Learn more about nutrition, exercise and mindful eating. Free lunch for students who RSVP to nutrition@ucsf.edu.
SYNAPSE NEWSPAPER
Wednesday, Oct. 9, noon-1 p.m., MU 123W, Parnassus Synapse is looking for Mission Bay and Parnassus writers, bloggers, photographers and designers. Come to the lunch meeting, share your story ideas and enjoy a free lunch. For more information, email synapse@ucsf. edu.
KEVIN HINES: THE MAN WHO JUMPED OFF THE GOLDEN GATE BRIDGE AND SURVIVED!
Wednesday, Oct. 9, noon-1 p.m., Health Science West, 301, Parnassus Kevin Hines’ story has touched millions, and he has dedicated his life to fighting for suicide prevention. Book signing follows the talk.
BUSINESS CAREERS FOR SCIENTISTS
Wednesday, Oct. 9, 5-7:30pm, Byers Hall, 212, Mission Bay Dr. Jenny Rooke is an investor and start-up utility player (C*, VP, BD) with a PhD in genetics, a bachelor’s degree in physics and a background in computer science. Dr. Rooke funds and builds companies that change the way science gets done with new tools and technologies.
OFF-CAMPUS CALIFORNIA ACADEMY OF SCIENCES: SHARKTOBERFEST NIGHTLIFE
Thursday, Oct. 3, 6-10 p.m., Cal Academy, Golden Gate Park Take a bite (and a sip) out of NightLife this week as Sharktoberfest returns! Sample local beers. See newly filmed footage of great white sharks and hear from Academy research associates David McGuire and Wallace J. Nichols during a talk titled “Surviving the Shark.” http://bit.ly/NightLifeTickets, http:// bit.ly/CLSDiscounts.
OFF THE GRID: UPPER HAIGHT
Thursday, Oct. 3, 5-9 p.m., Stanyan and Waller Streets, SF Off the Grid is a roaming mobile food extravaganza that travels to different locations daily to serve delicious food, with a free side of amazing music, craft and soul.
FRIDAY NIGHTS AT THE DE YOUNG
Friday, Oct. 4, 5-8.45 p.m., de Young Museum, 50 Hagiwara Tea Garden Drive, Golden Gate Park Friday Nights at the de Young offer a variety of interdisciplinary arts programs, including live music, dance performances, film screenings, panel discussions, lectures, artist demonstrations, special performances, hands-on art activities and more. Programs are free and open to the public, but do not include admission to the museum’s galleries.
HARDLY STRICTLY BLUEGRASS FESTIVAL
Friday, Oct. 4-Sunday, Oct. 6, 11 a.m.-7 p.m., Hellman’s Hollow (formerly Speedway Meadows), Golden Gate Park San Francisco’s own Hardly Strictly Bluegrass is one of the largest (and free-est) music festivals in the country. This flurry of banjos (and many other instruments) will take place in Golden Gate Park, and no tickets are required. http://bit.ly/SFbluegrassFest.
BANK OF AMERICA FREE MUSEUM WEEKEND
Saturday, Oct. 5-Sunday, Oct. 6, various locations, SF Holders of Bank of America credit cards and debit cards get free admission to several Bay Area museums for one weekend each month. http://bitly.com/BofAmuseums
synapse.ucsf.edu | October 3, 2013 | 3
ANNOUNCEMENTS
research scientists and faculty are all eligible to apply. Applications will be available online Friday, Oct. 4 on SEP’s website: ucsf.edu/sep.
REGISTER TO VOTE: GENERAL ELECTION ON NOV. 5
Registration cards must be received by Oct. 21 if you are to be eligible to vote in an upcoming election. You may also register to vote online. http://bit.ly/12HkQ5d.
SEP RECRUITING FOR 20132014 CLASSROOM PARTNERSHIP PROGRAMS
The Science and Health Education Partnership (SEP) offers opportunities for UCSF volunteers to work with San Francisco K-12 teachers to co-plan and co-teach four investigative science lessons in the teachers’ classrooms during the spring semester. The commitment is only 20 hours, flexibly scheduled from January to May. Professional students, graduate students, postdocs,
APPLY FOR A MS IN GLOBAL HEALTH SCIENCES
The master’s degree program in Global Health Sciences will be accepting applications through Feb. 15 for the 2014-15 class. This will be the inaugural class at Mission Hall on the Mission Bay campus. Visit the website for more information. globalhealthsciences.ucsf. edu/education-training/masters-program.
UCSF GLOBAL HEALTH SCIENCES INFORMATION SESSION
Wednesday, Oct. 23, 12 noon-1 p.m. Room C-130, Parnassus UCSF Global Health Sciences will hold an information session about its master’s degree program. The session will be led by Madhavi
Dandu, MD, MPH, and Kim Baltzell, RN, PhD, MS, Program Directors and Medical School alumnae. There will be ample time for questions and answers. Light refreshments will be served.
CAMPUS POETS & WRITERS
Join an ongoing, informal workshop facilitated by UCSF author Dr. David Watts. Beginners welcome, bring a poem or a short prose piece, or just come to listen. Group meets Mondays 4:30-5:30pm, 350 Parnassus, #900. Contact: hdwatts@comcast.net.
CLASSIFIEDS RETAIL STORES FOR RENT
Sunset SF retail stores for rent: $3,200/ month each, 2132 & 2134 Taraval Street, easy transportation, 1 bedroom, kitchen, full bath in the back of store. (415) 665-4567.
NEWS
Got a Bike? Like to Dance? Try SF Bike Party By T. Booth Haley Staff Writer
L
arge social bike gatherings have a long history in San Francisco. This month, Critical Mass, which was started in San Francisco, turns 21 years old. (Does this mean we may now drink during a Critical Mass ride?) In those days, there was little acceptance of bicycles on the roadways — cars dominated, and biking was dangerous and weird. Critical Mass was essentially a protest: riders were demanding roads that provided a safe space for bikes and challenging the status quo of thoroughfares that prioritized cars not only over bikes, but pedestrians and public transit as well. Attitudes have changed. Now bikes are begrudgingly accepted and are even trendy. Business people in suits ride them down Market Street, parents put kids in bike trailers and travel safely around town, and bike lanes can be found in every neighborhood. Perhaps the aggressive edge to the Critical Mass protest is not as relevant as it once was. A new style of social bike gathering has emerged: the Bike Party.
Synapse
UCSF to Become First U.S. Medical School Offering Credit for Wikipedia Articles The University of California at San Francisco will soon be the first U.S. medical school at which medical students can earn academic credit for editing medical content on Wikipedia. Wikipedia is one of the most widely used medical references in the world and the most consulted source for many health topics. But its medical entries can sometimes lack reliable sources and display gaps in content. “Wikipedia generates more than 53 million page views just for articles about medications each month, and is second to Google as the most frequently used source by junior physicians,” said Amin Azzam, MD, MA, an associate clinical professor at the UCSF School of Medicine, an instructor for the new class, which will be available to fourth-year medical students and start in December. “We’re recognizing the impact Wikipedia can have to educate patients and health care providers across the globe, and want users to receive the most accurate, publicly available, sound medical information possible.
Gladstone Scientists Win $12.5M in Prestigious Grant Awards
sfbikeparty.org San Francisco Bike Party meets every first Friday at 7:30 p.m. at a location that is announced on its Facebook page or on its website, sfbikeparty.org.
Bike Party started in San Jose six years ago, making it perhaps that city’s greatest contribution to human culture. Its website describes it thus: “We’re one-half political
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About
Synapse is the UCSF student-run weekly newspaper, which runs on Thursdays during the academic year and monthly during the summer. Synapse seeks to serve as a forum for the campus community. Articles and columns represent the views of the authors and not necessarily those of the Board of Publications or the University of California.
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Announcements and letters should be submitted six days before publication. All submissions can be either emailed or mailed. All material is subject to editing. Letters to the Editor must be signed by the author.
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Paid advertisements do not necessarily reflect the views of Synapse. Synapse and its editorial board reserve the right to decline advertisements promoting false or misleading claims, known health risks, or content deemed by the editors to be antithetical to the interests of UCSF students or the UCSF community. Synapse does not accept advertisements from tobacco or alcohol manufacturers, or sexually oriented personal ads. Synapse reserves the right to run any ad with a disclaimer.
party, one-half street party — made up of all types of bicyclists and human-powered transportation advocates who celebrate and build community in a monthly ride that must be experienced to be understood.” Soon, San Francisco and the East Bay had started Bike Party groups of their own, and the party continues to spread to cities further afield. The crucial difference between Bike Party and Critical Mass is that Bike Party follows all traffic laws. This shifts it from the realm of civil disobedience to that of civic celebration. The group tries to cultivate positive relations with cars, making sure to let the death machines through intersections and make turns as needed. Also, it has lots of LED light-art, huge sound-systems pulled on bike trailers and riders stop at two or three parks every ride for temporary dance parties. For all these reasons, Bike Party has assumed the throne as the pre-eminent social bike gathering in San Francisco. San Francisco Bike Party meets every first Friday at 7:30 p.m. at a location that is announced on its Facebook page or on its website, sfbikeparty.org. The route changes every month. Everyone with any interest is encouraged to join and is made to feel quite welcome. Bike Party is one of the friendliest, merriest gatherings one can find in this town. (For true believers, East Bay Bike Party, which is perhaps four times bigger than San Francisco Bike Party, occurs on the second Friday of every month and always starts and ends conveniently near BART stations).
T. Booth Haley is a fourth -year dental student.
Three scientists with the Gladstone Institutes have won research awards from divisions of the National Institutes of Health (NIH), equaling an approximate total of $12.5 million over five years for their groundbreaking research to overcome HIV/AIDS. The NIH’s National Institute on Drug Abuse (NIDA) in August awarded Warner C. Greene, MD, PhD, a 2013 Avant-Garde Award for HIV/AIDS Research. Set up to fund individual scientists of exceptional creativity who are conducting high-impact research that may lead to ground-breaking avenues to prevent or treat HIV/AIDS, this award will mean approximately $5 million in new HIV/AIDS funding for the UCSF-affiliated Gladstone Institutes. At the same time, the Office of the Director of the NIH this week presented Gladstone associate investigator Leor S. Weinberger, PhD, with an NIH Pioneer Award. This award is also for a total of roughly $5 million for Weinberger to use for his highly innovative approach to HIV/AIDS research. Also this week, the Office of the Director of the NIH presented Gladstone assistant investigator Shomyseh Sanjabi, PhD, with an NIH New Innovator Award worth roughly $2.5 million. The award is given to young investigators doing innovative research.
Orofacial Sciences Professor Wins National Award Maria Orellana, DDS, PhD, Health Sciences Associate Clinical Professor in the Department of Orofacial Sciences, has been honored with the 2013 Colgate Palmolive National Outstanding Faculty Award. The award was announced in a letter from Maritza Morell, DMD, MS, MPH, President of the Hispanic Dental Association (HDA), and will be presented at the 23rd Annual Meeting and Expo of the HDA in Boston on September 27-28. Dr. Orellana had this to say of her award, “I thank you all for your support, and for being great role models in our efforts to improve the oral health of underserved communities." Orellana's research program focuses on identifying and characterizing issues of disparities in access to oral health care in minority children and adolescents. Specifically, it focuses on disparities in access to orthodontic care in Latino children and adolescents.
4 | October 3, 2013 | synapse.ucsf.edu
NEWS
Panel to Spar Over Gene Patents
By Benjamin Cohn Staff Writer
F
irst, something we can all agree on: As a society, we value innovation, and our governments make special considerations to protect the people who create valuable new tools, techniques and medicines. Our patent system, for example, grants pharmaceuticals and biotech companies a limited monopoly to recoup the costs of bringing their products to market and to patients. As a rule, patents are granted only for ideas that are novel, useful and non-obvious. While this seems simple enough, interpretation of patent law can be complicated, and it gets even murkier when applied to living, biological systems. For example, should people be allowed to patent genes? The U.S. Supreme Court said “no” this past July, when it decided that Myriad Genetics shouldn’t be allowed to hold This House Believes Genes p a t e n t s Should Be Patented over the human Monday, Oct. 7, 6-9 p.m., genes Genentech Hall, Byers Audito- B R C A 1 rium (GH 106) a n d Mission Bay BRCA2, variants of which predispose certain individuals to developing breast cancer. This ruling overrode two previous decisions by the U.S. Court of Appeals for the Federal Circuit (CAFC) in Myriad’s favor, and it upheld a 2010 judgment against Myriad by the United States District Court for the Southern District of New York. That this case should proceed all the way to the Supreme Court reflects the contentious nature of the issues at stake, and makes this a landmark case for molecular biology and patent law. To explore the legal, moral and health care issues surrounding gene patents and the Myriad decision, as well as the implications for bio-entrepreneurship and innovation, Oxbridge Biotech Roundtable-Bay Area invites the local community to convene at UCSF on October 7 for an expert-led debate. Guest speakers will include Jacob Sherkow, Fellow at the Stanford Law School Center for Law and the Biosciences; John West, CEO of the genome diagnostics company Personalis; Mildred Cho, Associate Director at the Stanford Center for Biomedical Ethics; and William Gunn, Head of Academic Outreach for the reference manager software Mendeley.
The Myriad case is framed around a simple question: “Are isolated human genes patentable?” The argument against Myriad’s claims to patents over BRCA1 and BRCA2 essentially asserts that merely isolating DNA that is identical in sequence to its naturally occurring counterpart contains no “inventive step,” and thus that isolated genes are unpatentable products of nature. In 2010, Judge Robert W. Sweet of the U.S. District Court for the Southern District of New York wrote: “DNA represents the physical embodiment of biological information, distinct in its essential characteristics from any other chemical found in nature. It is concluded that DNA’s existence in an ‘isolated’ form alters neither the fundamental quality of DNA as it exists in the body nor the information it encodes.” However, Myriad argues that isolated DNA is, in fact, different in character from naturally occurring sequences, being “substantially separated from other cellular components which naturally accompany a native human sequence, such as human genome sequences and proteins.” Indeed, the U.S. Patent and Trademark Office (USPTO) had granted patents to about 2,000 isolated human genes before this case, based on the premise that isolated genes are real, tangible molecules and thus should be treated no differently than any other chemical compound. Proponents argue that investors initially put money into Myriad based on expected premium pricing of its services and the promised ability to defend its patents over 20 years, funds that allowed Myriad to rapidly sequence BRCA2 and develop the associated diagnostic tests. They say that such patents encourage investment in biotechnology and actually promote innovation in research. Opponents contend that Myriad’s claims to these patents restrict research for clinicians, limit scientific progress and are ultimately detrimental to patients, because the lack of competition would keep testing costs high and preclude the possibility of seeking a second opinion. What do you think? Please join OBR-Bay on October 7 for a lively evening of debate. Register for free at tinyurl.com/OBRBayGenePatentDebate.
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Benjamin Cohn is a fourth-year Biomedical Sciences student at UCSF/Gladstone Institutes and a correspondent for Oxbridge-Bay chapter.
Power of Music » FROM HOME PAGE
dents will forever be ingrained in my memory. But after each FPC interview, I am always left with that uncomfortable feeling of taking — be it emotions or stories or lessons — without giving anything back. A few months after school started, I walked into a patient’s room for the first time as a musician, alongside Chaplain Pegi Walker. What if the patient doesn’t like the violin? What if he/ she requests something I don’t know how to play? What if the music is too loud? What if I mess up? These were all the thoughts going through my head. But as soon as I started playing, I realized that it wasn’t about me, or my playing. It was about the music, and how the notes brought patients to another world, sometimes laden with emotions, other times filled with nostalgia. Some patients use the music to break the boredom of hospital TV; others use it to distract unrelenting pain. Patients always thank me for bringing music into their rooms, but what they don’t realize is how thankful I am to have shared a moment in their recovery. And after the music is over, I have been blessed to witness the wonders that Chaplain Walker brings to each patient. I have seen the strongest patients open up to their deepest fears, and I have prayed with the most faithful. This is the part of patient care that I enjoy the most, and I am extremely lucky to be able to do so with Music Is Good Medicine. For us, as students in the health professions, Music Is Good Medicine is not just a way to give back to the countless patients who teach us various skills. It is an invaluable way to learn about what it means to be a patient at the hospital and about alternative methods of healing. It is a great way to escape the demands of school without losing sight of why we chose our professions. It is also not only about the patients. Countless nurses, hospital assistants and visiting family members benefit from having music fill the halls. To anyone who sings or plays any type of instrument, please consider joining Music Is Good Medicine!
Catherine Chiu is a second-year medical student.
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synapse.ucsf.edu | October 3, 2013 | 5
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STEM CELL BIOLOGY: MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Judson, R.L.; Greve, T.S.; Parchem, R.J.; Blelloch, R. Nature Structural and Molecular Biology. September 15. [Epub ahead of print]
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MicroRNAs are known for regulating families of related genes by targeting the genes for degradation. Because of this propensity to alter the regulation of whole gene families, instead of individual genes, miRNAs are often eyed as the drivers of cellular events that require a large change in gene transcription, such as cell differentiation. In this paper, researchers screened fibroblast cells going through de-differentiation into induced pluripotent cells (iPSCs) to look for changes in different miRNAs, and found that the mir-181 family was a novel enhancer of iPSC reprogramming. During normal iPSC reprogramming, the mir-181 family is upregulated and when the mir-181 family was inhibited, they saw fewer clusters of iPSCs in cell culture. Along with the mir-302/294 family (which has previously been identified as a driver of de-differentiation), the mir-181 family works together to inhibit a set of 25 genes that normally prevent de-differentiation into iPSCs. IMMUNOLOGY: Type 2 innate lymphoid cells control eosinophil homeostasis. Nussbaum, J.C. et al. (Locksley). Nature. September 15. [Epub ahead of print] Eosinophils are a cell type that help protect us against parasite infection; unfortunately, they also often contribute to inflammatory diseases such as asthma. One surprising and odd discovery about eosinophils made long ago was that they seemed to exhibit some type of circadian rhythm: one study found that individuals with high eosinophil numbers tended to have the most in the evening and significantly fewer during the day, though the cause of this cycle was never identified. Circadian rhythm can also influence other cell types, too. In this paper, researchers linked circadian rhythm to eosinophil prevalence and activity through type 2 innate lymphoid cells (or “ILC2” cells), an extremely rare cell type that reside in peripheral tissues and are thought to contribute to Th2 (or “allergic”) disease. Normally, ILC2 cells secrete basal levels of IL-5 to promote a baseline level of eosinophil infiltration of the body. During inflammation, they will also secrete IL-13 and promote eosinophilic inflammation. Here, they found that circulating circadian rhythm factors interact with ILC2 cells and cause them to secrete larger amounts of IL-5, a cytokine that promotes eosinophil generation and homeostasis. This way, ILC2s promote the circadian cycling of eosinophil levels through IL-5. PHYSIOLOGY: Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading. Kubota, T. et al. (Bikle). Acta Astronautica. 92(1):73-78. Physical stress is one thing required to keep our bones strong. Constant loading and unloading of weight onto our bones helps to “remind” them to maintain their strength and prevents breakdown of the minerals in our bones in favor of other organs that could use those minerals otherwise. This phenomenon explains why astronauts must keep to such stringent exercise regimens: if they didn’t, their bones would become profoundly weak and could even break upon normal activity back on earth. Insulin-like growth factor-1 (IGF-1) is a hormone involved in the homeostasis of bone formation and catabolism, and in this paper, researchers wanted to determine if its function was linked to bone stress. To test this, they unloaded bone stress from either wild-type or IGF-1 receptor knockout mice and looked at the rate of bone strengthening upon bone reloading. IGF-1 receptor knockout mice had loss of periosteal bone reformation but normal endosteal bone reformation, indicating that the hormone’s role in bone homeostasis is at least in part linked to bone stress. IMMUNOLOGY: Circadian gene Bmal1 regulates diurnal oscillations of Ly6Chi inflammatory monocytes. Nguyen, K.D. et al. (Chawla). Science. 341(6153):1483-8. As mentioned above, some innate immune cells, such as ILC2 cells and eosinophils, exhibit circadian regulation, which can contribute to different strengths of immune processes at different times of day. Researchers have been interested in how many other immune cells respond to circadian rhythm as well, and monocytes (a very ubiquitous but still quite mysterious cell type) are one example. Here, researchers found a change in inflammatory blood monocyte numbers depending on the time of day, which even translated to a susceptibility to Listeria bacterial infection depending on the time of day that the bacteria were introduced. This regulation was shown to be dependent on the circadian regulator BmaI1. When BmaI1 was deleted, the mice became susceptible to a number of inflammatory conditions, indicating that circadian regulation helps to carefully control the potential for immune-mediated inflammation.
Alexandra Greer is a sixth-year Biomedical Sciences student. For comments or paper suggestions, email Alexandra.Greer@ucsf.edu.
6 | October 3, 2013 | synapse.ucsf.edu
Rockey
Piled Higher and Deeper by Jorge Cham
www.phdcomics.com
Retaining young scientists
promising young scientists to stay in academic research, according to Rockey. The centerpiece of this goal is the BEST program: Broadening Experiences in Scientific Training, which provides grants for institutions (of which UCSF is one of 10) to better prepare biomedical students for careers in research. Grants were reviewed in August, but it remains to be seen how this program will change graduate education at UCSF. Other initiatives include a push to reduce the length of graduate training by limiting NIH funds to five years, provide more “bridge” funding for the last year of postdoctoral training and increase the pay of postdoctoral researchers across the country, according to Rockey. “We have been scientific leaders since World War II,” said Rockey. “We are a technology and technologically based economy — innovation based. That’s what drives us and drives us forward to being a strong economy. And yet, we are not investing in science.” For more information on Dr. Sally Rockey’s perspective and ideas on improving research funding, visit her blog, “Rock Talk,” at http.//nexus.od.nih.gov/all/category/blog.
It may come as a surprise to many trainees, but the NIH’s goal is to encourage these
Alexandra Greer is a sixth-year Biomedical Sciences student.
» FROM HOME PAGE
the steward of biomedical and behavioral research in the United States. So how can the NIH do more with less? One way to encourage more scientists to continue applying for NIH grants — and more generally, to stay the course — is to provide extra review for those already awarded more than $1 million in NIH extramural funding, according to Rockey. This “second look” encourages a more critical review of grant proposals written by well-funded PIs, with the eventual goal of maintaining a diverse group of funded laboratories. Additional programs include U01 grants intended to maximize collaboration with NIH hospitals. Task force created Those in charge at the NIH are also keenly aware that these difficulties may serve to discourage talented young scientists from remaining in academic research. The NIH recently launched the Biomedical Research Workforce working group, which included significant involvement from UCSF’s Keith
title: "Your Graduation" - originally published 9/27/2013
Yamamoto, Vice Chancellor for Research in the School of Medicine. Considering that 70 to 75 percent of the biomedical workforce is comprised of PhDs, the workforce working group focused its work on PhD researchers. The data are overwhelming: Young scientists are being forced to deal with an increasingly protracted training period, due to the funding crisis. Currently, the average age of investigators who successfully receive their first R01 award, the common metric of success as an independent scientist and the pri-
MIND&BODY
SuperBetter to the Rescue! By Nicole Croom Staff Writer
D
o you smell that? That panic-inducing pheromone that permeates the air of every school campus, sports competition and office building on the planet? Yes, that is the oppressive stench of stress in the air. The herald that tells you that summer vacation (if you were lucky enough to get one) is truly over, and that school is officially in session. But fear not, you are not alone in your struggle to keep from drowning in the anxieties that have been added to your life by the start of a new academic year. There’s help in the form of a free online game named SuperBetter that is designed to help you defeat any darkness in your life. And even if you’re not a student facing the stress of school life, you can still benefit from playing SuperBetter by selecting a “Power Pack” that applies to the problems in your life, whatever they may be. SuperBetter was featured in a fairly recent TEDTalk given by the game’s creator, Jane McGonigal. The talk is available to watch on Netflix under the umbrella of “TEDTalks: Life Hack.” In her presentation, McGonigal describes how the effects of a traumatic brain injury pushed her into a deep depression. The pain was so debilitating that she was completely confined to her room for three months, unable to engage in any of the everyday activities we take for granted, because they might set off her symptoms. It was when she began to consider suicide a viable option for escape that she came up with a way to turn her post-traumatic stress into “post-traumatic growth.” She decided to turn her recovery into a game. The game is simple: Choose a secret identity, recruit some awesome allies, battle bad guys and activate power ups. When you first create your account, there is a short introduction (if you’ve watched the TEDTalk, you can breeze through it) that explains the science behind the game and the four types of resilience the game helps you to build, to give you the strength to handle anything life throws at you. They’re pretty straightforward. Physical resilience is amped up by completing power ups that keep you from being sedentary all
mary yardstick for biomedical laboratory financing, is 42 years old. The average age for all R01 awardees is now 53, indicating a significant skew of awards to older investigators. These numbers are discouraging for postdoctoral researchers in their 30s trying to plan the next stage of their careers — and their lives.
Ex Factor
» FROM HOME PAGE
and that the familiar is all too easy to fall back on, I know it is for comfort and pleasure alone and not meant to mean anything. I know these things and yet, because we haven’t discussed the implications of the act directly, I find myself wondering throughout: “Does this mean he wants to get back together? Are we FWBs? (Or Friends With Benefits, for those not in the know.) Is this the last time I will get to be with him?” All distracting thoughts that only serve to decrease my overall enjoyment of said hook-up. T h e s e thoughts also br i n g up t h e problem of the multitude of labels available for use on the relationship spectrum. Aren’t FWBs actually “dating”? Their dates just happen to be regulated to private quarters and not dinners out. When does “dating” become “official”? What’s the difference between hooking up with the same person multiple times and an FWB? Bottom line: One, labels are stupid. Two, if you are going to hook up with an ex, you need to understand the exact nature of the
“
day. Mental resilience is increased via power ups that engage your brain. Emotional resilience is created when you use power ups to follow the 3:1 positive emotion ratio, that is, you experience three positive emotions for every negative one over the course of a certain period of time. And the last, social resilience, is earned by activating power ups that encourage you to reach out to others. After the intro, you choose one problem to focus on. You can pick from an extensive list that includes chronic pain, depression, stress reduction and weight loss. From there you choose whether to create your own adventure or to get help choosing the proper “Power Pack.” This is designed with the quests, bad guys and power ups you will need to neutralize or utilize on your SuperBetter journey, in order to vanquish your chosen villain. Of course, to get the most from the game, you actually have to use it. I’m the type of person that gets into having a secret identity. I like having concrete quests to accomplish each day that rack up points. Quests that involve engaging in activities that I have thought about doing but never quite had the motivation for, such as meditating daily, which helps to boost my mood and reduce my stress levels when I actually take the time to do it. I encourage everyone to try it, but your success will depend on how seriously you decide to take your adventure. So take a nice big whiff of that stress-filled atmosphere and decide: Are you ready to become my SuperBetter ally?
Nicole Croom is a second-year student in the School of Medicine.
hook-up before you engage. You need to talk about what you each want this to mean (or not mean), to determine if this is strictly a one-time thing, just for fun, or the beginning of a fresh start. Understanding may not stop it from feeling like your heart got bitch-slapped by a body builder afterwards, but it will stop you from having unrealistic expectations, and maybe give your willpower the boost it needs to turn your ex away if you know for certain that it will only end up in one of you being hurt. Yes, I know it’s nice to be with someone who knows your body and who is safe and familiar (trust me, I know), but it’s just a short-acting anesthetic for your inability to be happy with your single self (which, let’s face it, is an impossibility for most, since even when you’re not in a relationship, you use your friends for all your social, if not sexual, needs). If the possibility of a hook-up with your ex comes up, and you have a discussion beforehand and know that it will lead nowhere and that you will feel like crap afterwards but you still decide to go for it anyway, then I have one thing to say to you: (Shrug.) It happens. Want some chocolate?
I find myself wondering throughout: “Does this mean he wants to get back together? Are we FWBs? (Or Friends With Benefits, for those not in the know.) Is this the last time I will get to be with him?”
synapse.ucsf.edu | October 3, 2013 | 7
Chancellor
OPINION
» FROM HOME PAGE
lor spoke about the OME Precision Medicine conference held at UCSF last year that included the heads of the National Institutes of Health, Food and Drug Administration and the Institute of Medicine, as well as California Governor Jerry Brown and Facebook founder Mark Zuckerberg. “What UCSF does really well,” she said, “is convene.” Achievements at UCSF Chancellor Desmond-Hellmann continued this theme of collaboration as she pointed out the achievements of “[some people] you should know,” individuals who are making great contributions to the UCSF community. Dr. Hana El-Samad was featured in the area of research. Dr. El-Samad is using engineering and mathematical tools to understand how cellular systems behave. This inherently interdisciplinary study is manifested in Dr. El-Samad’s work. As Chancellor Desmond-Hellmann quipped, “Almost everyone on the fourth floor of Byers Hall was a co-author” on Dr. El-Samad’s last paper. Next, the Chancellor showcased Dr. Jeff Olgin’s work on expanding the Framingham Heart Study — which yielded many of the now classical risk factors for heart disease — into the modern era. To do this, Dr. Olgin created the eHeart program, by partnering with private industry and entrepreneurs to create mobile technology that will make it possible to monitor the hearts of one million people. Finally, in education, the Chancellor highlighted the work of Dr. Elizabeth Watkins, Dean of the Graduate Division and ViceChancellor for Student Academic Affairs. Dr.
Watkins’ unique background as an historian of science allows her to manage this dual role and integrate all of the professional education programs.
By Marissa Cruz Contributing Writer
Challenges facing UCSF Along with these great achievements, Chancellor Desmond-Hellmann discussed some of the more challenging headlines of the year. Sequestration has taken a major toll on basic research funding, causing many researchers to scale back projects; the chronic decrease in funding from the state has made it difficult to maintain a world-class educational enterprise; and the imminent implementation of the Affordable Care Act is putting pressure on the Medical Center. However, the Chancellor sees UCSF enacting solutions in all three of these areas by increasing our lobbying efforts in Washington, D.C., to ensure that legislators understand the importance of basic science research; creating new team-based and technology-oriented curricula that will create more value in education; and creating a UCSF Accountable Care Organization to improve efficiency at the Medical Center. Though these are certainly difficult times, Chancellor Desmond-Hellmann nevertheless sees opportunity in them, because of the people who make up UCSF. In her closing remarks, she emphasized the role that each member of the UCSF community has to play in the success of the campus, saying, “All of our stories are what make up [this] great institution.”
Brian Shaw is a first-year medical student.
Oligos For Your Application
N
urses are often portrayed as hospital clinicians, and are seldom seen as public health administrators who make house visits to assess their patients’ health care needs and see that their medications are properly taken. They brave the Tenderloin area early in the morning, although not always to deliver the care that nurses are typically expected to furnish. Here, rather than in formal, sterile environments with pristine equipment, they work in transitional housing units called SRO, or single-room occupancy hotels. For a nurse visiting for the first time, it can be shocking to see these living quarters. The problems the patients face on a daily basis are almost overwhelming. They face a Sisyphean cycle of combating chronic ailments and finding resources that are often hard to come by, as they try to muster enough energy and courage to get through the next day. San Francisco’s Tenderloin has had a notorious history of drug-related activity, and the SROs in the area now offer housing for the homeless. It is intimidating to enter these SROs, not because of the people who live there, but because of the lack of cleanliness and upkeep. We often encountered trash along the hallways, sometimes an empty syringe or open trash receptacles that hadn’t been emptied in a while. There were bulbs that needed to be replaced, and windows that could have used some cleaning. As you enter most of these buildings, you are immediately greeted by a foul and rancid smell emanating from the dilapidated carpeting, which is generally of a dark hue that hides the dirt embedded in its fibers. I could only imagine what it would be like to trek down these hallways on a rainy winter day. The walls are covered with grime and the ceilings with soot and lingering cobwebs. The walls are devoid of any pleasing pictures or artwork that could provide some relief from the overwhelmingly bleak surroundings. Sometimes, we could not enter a patient’s unit because there simply was not enough room for three people. The nurse would thus have to do the assessment outside, where the lighting was usually better, while carefully trying to ensure some level of privacy for the client. While driving to our next visit, we passed by the Kelly Cullen Residence, the old YMCA building that was converted into affordable housing for the homeless. Its namesake was a Franciscan monk and activist who found
Courtesy photo Marissa Cruz, RN, is a master’s of Science Candidate 2014 in the School of Nursing.
refuge in helping and caring for Tenderloin residents. “We need to see our patients in more buildings like that,” said the nurse in his slightly lilting Irish accent. Two visionaries — one voice. There is a responsibility that should tie people together when they see others suffering. Just knowing about it is not good for one’s health. Yet in the midst of modern life, one seldom sees smiles cast onto a passing shadow. In the recesses of The City’s spleen, I witnessed them at every greeting — showing the resiliency of human frailty. Supportive housing for chronically ill, homeless people has been shown to cut the costs of their care for other medical sectors, relieving overburdened emergency rooms, and reducing in-patient hospitalizations, ambulance usage and psychiatric intakes, just to name a few of the medical interventions they might require. More importantly, case management within the housing residences can provide encouraging results, as well as contribute to community health and strength. We can move away from the “lost cause” paradigm by helping human beings to participate in opportunities for community-building and to contribute to society. People are still suffering on the margins of society, and it is not always easy for the arms of medicine to reach and embrace them.
Marissa Cruz, RN, is a master’s of Science Candidate 2014 in the School of Nursing.
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FOOD 8 | October 3, 2013 | synapse.ucsf.edu
Off the Grid: Upper Haight
Illustrations by Jillilan Varonin/BMS4
Chairman Bao
Little Green Cyclo
here I stood, staring at a mob of people stuffing their faces and a horseshoe of food trucks offering up seemingly endless variety. Then I spotted it. Off in the back corner (if a horseshoe has corners), the Chairman Bao beckoned. I really had no idea what I was getting myself into, considering this was the first time I had eaten Bao, but I will start off by saying that I have become a comrade. Bao is essentially a deconstructed Chinese bun. The Chairman offers both a steamed and baked version, just as any dim sum place will offer a steamed or baked bun. Like any good hungry Baoist, I ordered one of each: the baked pork belly and the steamed spicy chicken. The baked pork belly bao was about the size and shape of a hamburger, but in place of the beef, there was an epic slab of pork belly that melted with every bite. This was topped with pickled daikon and green shiso, which added a nice tangy crunch. It was all surrounded by a light, flaky bun that held the scene together. The steamed spicy chicken was essentially a mini taco on a flat round pillow of a steamed bun. The chicken was indeed spicy, but in no way hot, and the spice was expertly balanced with the savory of the sesame sauce and tart of the pickled veggies. So the next time you’re at Off the Grid and want a filling but not too heavy meal, I recommend visiting Chairman Bao.
his bright green food truck features Vietnamese-inspired dishes and touts its sustainably sourced ingredients. The relatively short line and creative menu items like Sweet Potato Tater Tots and various Coconut Rice Boxes caught my eye. I sampled the Truffle Oil Garlic Noodles with Lemongrass Organic Tofu ($9). The heaping helping with plenty of fried tofu left me full, but any truffle flavor that might have been present was overpowered by the lemongrass. The tofu spring rolls ($6) with a modest serving of peanut dipping sauce were fresh and perfect for sharing. Bottom line: Little Green Cyclo delivers when it comes to tasty vegetarian (and nonvegetarian) options and will leave you with some leftovers.
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Matthew Nordstrom/MS2
Curry Up Now!
A
s messy as the concept might sound, the deconstructed samosa at Curry Up Now! still managed to be visually appealing, with bite-sized pockets of golden deep-fried dough nestled in paneer, chopped onions, chickpeas, tomatoes, pico de gallo and chutney. If paneer, a chewy and refreshing farmer’s cheese, is not your cup of chai, you can substitute chicken, beef or tofu at no cost, or add lamb or pork belly for $2 more. Although there’s something comforting about biting into a crispy samosa stuffed with potatoes, peas and spices, I think I like the deconstructed version even better, with a higher filling-to-crust ratio that is not only satisfying, but also makes me feel a little better about myself. Less oil! More vegetables! I might as well be eating a spicy salad. Speaking of spices, those who don’t like their Indian food on the spicier side might want to look for alternative options.
Yi Lu/MS2
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Angela Broad/MS1
truck in The City and I just had to try it. So I decided to brave the long line and try their Filipino fusion fare. Because no one likes a person who is still undecided when she gets to the front of a lengthy line, I decided to read the menu on my phone while I waited. On my phone, I learned that sisig is a traditional Filipino dish of marinated pork — traditionally made with meat from the pig’s head but here substituted with pork shoulder. You can order tacos, burritos, fries, nachos, rice and salad, and add your choice of sisig pork, chicken or tofu. To try all three sisig options, I ordered two tacos (pork and chicken, $3 each) and the nachos with tofu ($8) for a fellow vegetarian Synapse reviewer. I also ordered a calamansi fruit drink (brand name Nomsi). I had never heard of the calamansi fruit, but the bottle assured me it was “wildly popular in Asia” and a “lusciously delicious” mix between a lime and a mandarin orange. I was not disappointed. The drink lived up to its glowing label. The tacos also lived up to my brother’s praise, with the pork being especially rich-flavored. The tofu on the tacos lacked the flavor of its meat sisig counterparts — a fine, if boring, dish overall. If you are headed to Off the Grid, I would strongly encourage you to give it a try, especially if you eat pork.
con, it’s hard to even write about, let alone relive the memory. The pre-packaged bacon strip was cold, like it was kept in a freezer until right before purchase. The temperature of the item was just wrong for fatty bacon. To continue the downhill trend of this dish, the taste was almost inedible, like the smell of the stale air of bacon cooked in the morning and left hanging around until late afternoon. Package that smell, freeze it, and take a bite. I couldn’t tell you when the item was made, but I assure you it was far too long ago for the dish to still taste good. Another selfproclaimed “bacon lover” Synapse reviewer decided to give the bacon a try and agreed it was terrible. Unable to finish the whole strip of bacon, the trashcan was forced to eat the rest.
Jillian Varonin/BMS4
Vegan Choices
Thinking back to how excited I was to try Señor Sisig’s fare, I was probably setting myself up for disappointment. The people waiting in line for Señor Sisig, easily one of the more popular trucks at Off the Grid, probably weren’t exercising their patience for nachos and tofu. Sure, the tortilla chips were crispy and the nacho cheese was appropriately nuclear yellow, but it didn’t really offer much more than I could have gotten at a Dave and Busters. The under-seasoned tofu limply lying in those pools of salty cheese didn’t bring anything to the table either.
Yi Lu/MS2
Phat Thai
A
s the name would suggest, Phat Thai fills Off the Grid’s Thai food niche. It serves the standard dishes that you can find at any Thai restaurant in The City, with the bonus of fast, phenomenal service and quality food presentation. Phat Thai’s saving grace is its educational and entertaining spice bar. Using Digimon evolutions as a guide to the levels of spice, the bar provides a description of each sauce and the dishes with which they pair well. I tried their signature Pad Thai ($8) with a Thai iced tea ($3). I chose to go vegetarian and was pleased with the variety and amount of veggies in the dish. I’m not a big fan of faux meat, so I was also relieved to only receive one piece of tofu, although that made me question whether its inclusion was accidental. As a fan of spice who has sensitive taste buds, I played it safe and paired it with the Level 2 spicy sauce, Sriracha with garlic and chili flakes. This definitely gave the dish the extra kick it needed. The tea was standard.
Nicole Croom/MS2
Bacon For dessert, I decided to try the chocolate covered bacon ($3) from the Bacon truck, which features dishes including a bacon burger ($9), bacon fried chicken ($9) and bacon grilled cheese ($8). There were so many things wrong with the chocolate-covered ba-
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he longest line at Off the Grid on the night I went was at Señor Sisig. Just the day before my older brother had told me that Señor Sisig was his favorite food
D
espite the variety at Off the Grid, vegans face a couple of obstacles. And if you’re like me, and you’re a vegan who doesn’t swoon over burritos, this food spectacle can be less appealing. However, I found a few gems to help guide you through the rough. From Chairman Bao, picky vegans (I prefer to describe myself as a Buddhist vegetarian, FYI), can nibble on a crispy miso-cured tofu and baby choy sum bao (bun sandwich). Remember to request no garlic-tofu mayo. Even without the extra dressing, this bao is a delicious bite. The tofu is lightly crispy on the outside, and tender just beneath the surface. The bao is similar to the buns served at traditional Chinese restaurants, only it’s softer and less greasy. At Little Green Cyclo, you can find a variety of tofu and vegetable dishes and banh mi, but the real attraction here are the sweet potato tater tots. Try the vegan mango ketchup that goes with an order of tots. Moving on to the Slider Shack, you’ll find the Black Bean Slider, which boasts 11 unique ingredients. Unfortunately, you’ll have to substitute a green chili sauce for their mango yogurt sauce. This bean patty was dense and lacked flavor. However, they use Hawaiian sweet buns instead of regular hamburger buns, which is a clever (and tasty) idea.
Geraldine Tran/MS2
ARTS&CULTURE
Bonnie and the Bang Bang Lights Up the Library By Angela Castanieto Associate Editor
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Señor Sisig
Jillian Varonin/BMS4
he music of Bonnie and the Bang Bang sounds as if it would be best enjoyed from the back of a smoke-filled, dimly lit roadside bar, but maybe that’s just me. The Oakland band’s 2013 album The Dark Dream, for the most part, pervades the senses with what they term “thrash folk” — that is, energetic blows of guitar, banjo, keyboard and drums with an almost Western sound. Accompanying dark-themed lyrics that are often partly shouted by frontman Patrick
James Stiles, this music definitely does not beg for a quiet setting. It was surprising, then, that Bonnie and the Bang Bang’s acoustic set last week at the UCSF Library, part of Campus Life Services Arts & Events’ Music in the Library series, was so successful. Stiles remarked on the great acoustics of the room and on the fact that “Nobody in the band is actually named Bonnie,” as the band warmed up the gathering of UCSF students and staff with what they called their “light stuff.”
BANG BANG » PAGE 10
synapse.ucsf.edu | October 3, 2013 | 9
PUZZLES
Piled Higher and Deeper by Jorge Cham
The Weekly Crossword
ACROSS 1 Contend with 5 Map collection 10 Weeps 14 High point 15 60's symbol 16 Storm harbinger 17 Trailer's place 18 Boredom 19 Fit as a fiddle 20 Plant life 22 Explored underwater 24 Up for the job 26 Blue-green color 27 Car cover 30 Golf attendant 32 Bumbling aunt on "Bewitched" 36 Tall flower 38 Beer mug 39 Smooth 40 Sudden outpouring 42 St. Petersburg's river 43 What some become in old age 45 Squirmy one 47 Chaotic situation 48 Arsonist's goal 49 Nightmare street 50 Otherwise 52 Meat from 1-down 54 Higher court 58 Synagogue leader 62 Told a tall tale 63 Type of squash 65 Springsteen's "____ in the USA" 66 Fabric flaw
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title: "The Cult of Academia" - originally published 9/16/2013
Grad School Illustrated
by Jillian Varonin
68 71
Copyright 2013 by The Puzzle Syndicate
67 Trunk of the body 68 Prepare for publication 69 Make eyes at 70 Knock follower 71 Building block
9 Paris waterway 10 Austrian money 11 Saintly king of Norway 12 Bundle of hay 13 Put the pedal to the metal 21 Lesson for toddlers DOWN 1 Farm newborn 23 Carplike fish 2 October 25 Backslide Week of 9/30/13 - 10/6/13 birthstone 27 Grace word 3 Money for 28 Poe bird Miguel 29 Concert venue 4 Background 31 Southern actor speech, sometimes 5 Jungle dweller 6 Became 33 Fred Astaire's nervous sis 7 Long and lean 34 Take pleasure 8 Perceptiveness
35 Wake-up call? 37 Sharp side of a blade 38 Confiscate 41 Type of drapery rod 44 Calm period 46 Cogged wheel 48 Guiding signal 51 Flooring choice 53 Word following record or address 54 Furthermore 55 Metallic sound 56 Ringing of bells 57 Civil wrong 59 Portend 60 Navy jail 61 Gung-ho about 64 And not
Edited by Margie E. Burke
Difficulty : Easy
www.phdcomics.com
HOW TO SOLVE: (Answer appears elsewhere in this issue)
Copyright 2013 by The Puzzle Syndicate
Jillian Varonin is a fourth-year BMS student.
OPINION
Time-Wasting Tips for the Overworked Grad Students: Reprobatio Certa By Alexandra Greer Science Editor
G
ot a long incubation time to kill? Waiting for your cells to spin? Bored in-between classes? In class? This week’s time waster will have you laughing — instead of crying — at manuscript rejection letters. For all my scientist friends out there, how many times have you hastily opened an email from a journal editor, expecting Christmas in July and a veritable chorus of compliments on your unexpected scientific breakthroughs, only to receive an equally hasty, rage-inducing, poorly researched diatribe on how your years’ worth of slaving in a dark mouse-infested laboratory “doesn't meet the criteria necessary for publication in our journal”? Obviously, this has never happened to me, but the answer is always “too many times,” no matter who you talk to. Usually, the way to counteract jour-
nal-rejection rage is to read your rejection letter 5,000 times until the words jumble up enough to start making some sort of sick, twisted sense. But no more; a new method is available! Reprobatio Certa, the blog of the Journal of Universal Rejection, catalogues recent manuscript rejections written by the nonexistent Journal’s crotchety editorial staff. The manuscripts — and rejection letters — may not be real, but the soul-crushing nature of the responses are hilariously (and uncomfortably) plausible. If there’s one thing that might make you feel better about that recent rejection, it’s watching someone else suffer your pain. It doesn’t hurt that it’s funny, too. Go to reprobatiocerta. blogspot.com to check it out. Check back for another grad-student-approved distraction — suggestions are welcome!
Alexandra Greer is a sixth-year graduate student in Biomedical Sciences and promises her PI that she doesn’t waste that much time in the lab.
MIND&BODY
Mama M.’s Soul Advice: Trapped Solution to Sudoku
D
ear Mama M., Help! I’m trapped in the lab ... because of myself! My advisor is really great and doesn’t pressure me to in the lab 24/7. Butwhen work I’m not there, all I can think not getting work done. about is how I'm lazy and how I’m It’ssobad, that every time Iwant to do something fun, there’s a part of me telling me thatI shouldn’t waste time and that I should be at work. This guilt is driving me cra zy. What can I do about it? Trapped ______________________________________
ing work. But that guilt, coming at you from all sides, causes you to kill yourself with working too much and then feeling bad when you are not working too much. This makes for an unproductive and unhappy life, sugar. Personally, I would start to put the guilt in the trash. You can dig it out later if you miss it. But, in the meantime, you
D
ear Trapped, Yikes! Your mind is working 24/7, both in and out of the lab, and you are still able to think of yourself as lazy? Where did you learn to be so unkind to your hardworking self? Is it possible that you inherited some guilt? Guilt can be generational. Often it is a cellular hand-medown … used clothing … recycled goods. So, I would first explore the roots of your guilt and check out if it really has anything to do with you or the events of your life. What are the origins of your guilt? Many of us come from lineages of horror, and surviving horror seems to twist us up a bit. So, there is some honor in guilt, I suppose, but it is a buzz-kill, so you have to decide what to do with it. I know that academic culture tells you that you are a lazy ass if you are not eating, breathing and sleep-
need to have some friggin’ fun. Sans guilt! You need to know that joy begets joy, and that a relaxed mind is fundamentally more productive than a stressed one. Get your Zen on, sweetie, and begin to understand the nourishment of Balance. There is a balance that you will need to find between work and life. Not just for now, but for always. Guilt is weighing you down, honey. Take some time to explore guilt. What is it? Where does it come from for you? Does it run deep, or is it just a nasty habit?
Are you actually trying to honor your ancestors with guilt? If so, honor them with love instead. Another bit of wisdom: Joy-energy can infuse your work, so when you are there, you will be more productive. (If you need more support in this struggle, pick up a copy of “Be Here Now” by Ram Dass). It seems ironic that the more fun you have in life, the more joy you bring to your work, and that leads to more productivity. But, trust me sugar, this has been studied and proven in so many arenas of work. I don’t believe in wasted time, and I don’t think you should either. Time is what you make of it, and it is always useful, even if you are doing “nothing.” Time expands and collapses with a certain kind of magic and mystery. It cannot actually be wasted. One last thing, about this balance thing: You will constantly struggle with trying to find and refine balance throughout your entire life. Start doing it now. It gets better the more you practice it and feel good about the practice. With fun and joy, Mama M.
Mama M. and her editor are health professionals at UCSF/San Francisco General Hospital, who understand the challenges that health professional students are confronted with. This column is a place where students can get honest, compassionate, humorous advice, wisdom and love. Send letters to MamaM. synapse@gmail.com.
10 | October 3, 2013 | synapse.ucsf.edu
ARTS&CULTURE
Bluegrass in San Francisco? Hardly... By Angela Broad Staff Writer
I
t’s one of the highlights of the San Francisco music calendar: the autumnal rite of Bluegrass —Hardly Strictly Bluegrass, that is. The three-day free concert featuring over 40 acts comes to Golden Gate Park this weekend, from Friday, October 4 to Sunday October 6. In its 13th year, the music festival will bring together legends of bluegrass, new banjo-picking acts and, as the name implies, bands from other genres. With so much tal-
Hardly Strictly Bluegrass Festival Friday, Oct. 4-Sunday, Oct. 6 11 a.m.-7 p.m., Hellman’s Hollow (formerly Speedway Meadows), Golden Gate Park San Francisco Admission FREE URL hardlystrictlybluegrass.com/2013/ ent in one place, it’s easy to get overwhelmed. Thinking back several years to my first Hardly Strictly Bluegrass, I was torn between seeing tried-and-true Emmylou Harris, and rolling the dice with rising stars Old Crow Medicine Show. This year, I’m planning to see timeless blues/rock singer Boz Scaggs and Natalie Maines of Dixie Chicks fame. I also did my homework and asked a bluegrass buff for some recommendations.
Rob Inglis, a first-year medical student who hails from North Carolina, is already planning his first foray into HSB. For those who want a true taste of the genre, he recommends folk singer Tim O’Brien, Ralph Stanley — a “giant of bluegrass”— and Patty Griffin, whom he considers “absolutely one of the best singer/songwriters in America today.” HSB offers up-and-coming bands equal billing with the greats. Inglis also plans to check out Trampled by Turtles, a “thrashgrass” band that puts on a “really fun show,” and Spirit Family Reunion, a band with a growing following, whose sound is reminiscent of gospel without the gospel lyrics. Into the indie scene? Jambase.com recommends The String Cheese Incident, Moonalice and Gogol Bordello. With all the amazing musical acts and low price of $0, it’s nearly impossible to go wrong, no matter which stage you end up at. Some of my favorite memories of Hardly Strictly Bluegrass have come from chatting with old friends and making new ones between acts. My best advice is to bring friends, a blanket and some beverages (permitted in non-glass bottles), and to just soak up the quintessential San Francisco experience. And when you’ve had your fill, spare yourself the inevitable trauma that is Muni after a concert, and plan to walk or bike home from Hellman Hollow. For a full lineup and more details, go to hardlystrictlybluegrass. com/2013/.
Angela Broad is a first-year medical student.
Bang Bang » FROM PAGE 8
Photo by Angela Castanieto/Tetrad5 Bonnie and the Bang Bang: (left to right) Joe Warren, Jake Dineen, Patrick James Stiles and Michael Pettett performing in the Lange Reading Room at the UCSF Library on Sept. 25.
This included songs found only on their 2012 EP Ode to Darkness, as well as songs from their latest release. The banjo, played by Jake Dineen, was given the spotlight during a dreamy rendition of the emotional “Simple Ships,” and Stiles even pulled out a melodica during their bluegrassy opener, “In Betweens.” The band charged into the second half of the set with the exquisitely near-dissonant guitar riffs of Joe Warren and of banjo player Dineen, who used a guitar slide to achieve the unique sound in the song “Medicine Man.” In addition to other songs from The Dark Dream, such as “I Ain’t Afraid of No Ghost” (lovely even without the keyboard), they surprised the crowd with a nicely harmonized cover of Miike Snow’s “Animal.” The highlight of the hour, however, was a haunting delivery of their song “Zombies! Pt. 1,” thanks in part to the band’s beautifully melancholy back-up vocals. Throughout the show, the band’s members remarked repeatedly that they should do these types of acoustic performances more of-
ten. This was a little unexpected, considering that their latest release has been regarded by some as rather aggressive when compared to their earlier sound. I felt fortunate to get a chance to hear some stripped-down, strings-heavy arrangements of the band’s repertoire, since it allowed each song’s basic musical elements to shine. To check out Bonnie and the Bang Bang, go to bonniehellabangs.com.
Angela Castanieto is a fifth-year Tetrad student.
Poetry at Parnassus [Untitled haiku] Walking into the library and seeing a priest — I almost confessed —Sarah Paris, UCSF staff
THE STRENGTH TO HEAL
starts with our scholarship.
Capt. Ana Morgan, M.D., HPSP Medical Recipient Brooke Army Medical Center, Texas
You can begin training for the career you’ve always dreamed of with financial assistance from the U.S. Army. Through the Health Professions Scholarship Program (HPSP)*, you could be eligible to receive a full tuition scholarship for an accredited medical program. The HPSP provides reimbursement for books, laboratory equipment and academic fees. You’ll also receive a sign-on bonus of $20,000 and a monthly stipend of $2,157. During breaks, you’ll have the opportunity to train alongside other members of our health care organization. To learn more, call (650)347-3967 or visit San Mateo Medical Recruiting Center 400 S. El Camino Real, STE 450 San Mateo, CA 94402 Email: usarmy.knox.usarec.list.9e3j@mail.mil www.goarmy.com/amedd.html
*Certain requirements and eligibility criteria apply. ©2013. Paid for by the United States Army. All rights reserved. Information subject to change.
Solutions
synapse.ucsf.edu | October 3, 2013 | 11
Solution to Sudoku
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12 | October 3, 2013 | synapse.ucsf.edu
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